abstract：BACKGROUND:Osteoarthritis (OA) of the knee is characterized by pain and activity limitations. In knee OA, proprioceptive accuracy is reduced and might be associated with pain and activity limitations. Although causes of reduced proprioceptive accuracy are divergent, medial meniscal abnormalities, which are highly preva...

journal_title：Osteoarthritis and cartilage

authors： van der Esch M,Knoop J,Hunter DJ,Klein JP,van der Leeden M,Knol DL,Reiding D,Voorneman RE,Gerritsen M,Roorda LD,Lems WF,Dekker J

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Matrix-associated autologous chondrocyte implantation has been used to treat cartilage defects. We developed a biphasic cylindrical osteochondral composite construct for such use, and conducted this study to determine its feasibility for treating osteochondral lesions in human knees. METHOD:Ten patients with...

journal_title：Osteoarthritis and cartilage

authors： Chiang H,Liao CJ,Hsieh CH,Shen CY,Huang YY,Jiang CC

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:Femoroacetabular impingement is proposed to cause early osteoarthritis (OA) in the non-dysplastic hip. We previously reported on the prevalence of femoral deformities in a young asymptomatic male population. The aim of this study was to determine the prevalence of both femoral and acetabular types of impinge...

journal_title：Osteoarthritis and cartilage

authors： Leunig M,Jüni P,Werlen S,Limacher A,Nüesch E,Pfirrmann CW,Trelle S,Odermatt A,Hofstetter W,Ganz R,Reichenbach S

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between anisotropic solute diffusion properties and tissue morphology in porcine temporomandibular joint (TMJ) discs. DESIGN:TMJ discs from eleven pigs aged 6-8 months were divided into five regions: anterior, intermediate, posterior, lateral, and medial. The transport propert...

journal_title：Osteoarthritis and cartilage

authors： Shi C,Wright GJ,Ex-Lubeskie CL,Bradshaw AD,Yao H

更新日期：2013-04-01 00:00:00

abstract：:Recent analyses of Col2a1-Cre; ROSA26R reporter mice showed that synovial fibroblasts in 7-day mice were LacZ positive, due to a history of Col2a1-Cre expression conferred by their origin in the interzone of the developing joint. We have examined LacZ staining in adult Col2a1-Cre(+/0); ROSA26R(LacZ) mice, with and wit...

journal_title：Osteoarthritis and cartilage

authors： Fosang AJ,Golub SB,East CJ,Rogerson FM

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To analyze knee trabecular bone structure and spatial cartilage T(1ρ) and T(2) relaxation times using 3-T magnetic resonance imaging (MRI) in subjects with and without tears of posterior horn of the medial meniscus (PHMM). DESIGN:3-T MRI from 59 subjects (>18 years), were used to evaluate PHMM tears based on...

journal_title：Osteoarthritis and cartilage

authors： Kumar D,Schooler J,Zuo J,McCulloch CE,Nardo L,Link TM,Li X,Majumdar S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Infrapatellar fat pad of patients with osteoarthritis (OA) contains multipotent and highly clonogenic adipose-derived stem cells that can be isolated by low invasive methods. Moreover, nuclear and cytoplasmic cellular extracts have been showed to be effective in induction of cell differentiation and reprogram...

journal_title：Osteoarthritis and cartilage

authors： López-Ruiz E,Perán M,Cobo-Molinos J,Jiménez G,Picón M,Bustamante M,Arrebola F,Hernández-Lamas MC,Delgado-Martínez AD,Montañez E,Marchal JA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Biomarkers provide useful diagnostic information by detecting cartilage degradation in osteoarthritis (OA), reflecting disease-relevant biological activity and predicting the course of disease progression. They also serve as surrogate endpoints in the drug discovery process. The aim of this narrative review was...

journal_title：Osteoarthritis and cartilage

authors： Mobasheri A

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:This article reviews original publications related to imaging in osteoarthritis (OA) published in English from September 2011 through March 2012. In vitro data and animal studies are not covered. METHODS:To extract relevant studies, an extensive PubMed database search was performed using the query terms "osteo...

journal_title：Osteoarthritis and cartilage

authors： Roemer FW,Guermazi A

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To confirm altered perfusion within tibial bone marrow lesions (BMLs) and improve our understanding on the relationship between BMLs and pain in knee osteoarthritis (OA). METHODS:Participants with moderate to severe knee OA were recruited and pain was assessed using the pain subscale of the Western Ontario a...

journal_title：Osteoarthritis and cartilage

authors： Seah S,Wheaton D,Li L,Dyke JP,Talmo C,Harvey WF,Hunter DJ

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVES:MicroRNAs (miRNAs) play an important role in the regulation of chondrogenesis of mesenchymal stem cells, but their expression still remains unknown in human adipose-derived stem cells (hADSCs). In this study the miRNA expression profile during chondrogenic differentiation of hADSC and the potential mechanism...

journal_title：Osteoarthritis and cartilage

authors： Zhang Z,Kang Y,Zhang Z,Zhang H,Duan X,Liu J,Li X,Liao W

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Obesity is a highly cited risk factor for knee osteoarthritis (OA), but its role in knee OA pathogenesis and progression is not as clear. Excess weight may contribute to an increased mechanical burden and altered dynamic movement and loading patterns at the knee. The objective of this study was to examine the...

journal_title：Osteoarthritis and cartilage

authors： Harding GT,Hubley-Kozey CL,Dunbar MJ,Stanish WD,Astephen Wilson JL

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:The objectives for this study were to determine whether radical initiated photopolymerizations typically employed for cell encapsulations lead to oxidative stress incurred by chondrocytes and whether the development of a pericellular matrix (PCM) decreases this oxidative stress and has longer-term benefits on...

journal_title：Osteoarthritis and cartilage

authors： Farnsworth N,Bensard C,Bryant SJ

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:As cartilage loss and bone marrow lesions (BMLs) are associated with knee joint pain and structural worsening, this study assessed whether non-invasive estimates of articular contact stress may longitudinally predict risk for worsening of knee cartilage morphology and BMLs. DESIGN:This was a longitudinal coh...

journal_title：Osteoarthritis and cartilage

authors： Segal NA,Kern AM,Anderson DD,Niu J,Lynch J,Guermazi A,Torner JC,Brown TD,Nevitt M,Multicenter Osteoarthritis Study Group.

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To assess the influence of pre-operative X-ray changes on the response to total knee joint replacement (TKR). METHODS:We included patients from one centre who underwent primary TKR (n = 478) for osteoarthritis in 2006 and 2007. The International Knee Society score (IKSS) and short form health survey were col...

journal_title：Osteoarthritis and cartilage

authors： Dowsey MM,Nikpour M,Dieppe P,Choong PF

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of short-wave diathermy (SWD) treatment in the management of knee osteoarthritis (KOA) and to assess whether the effects are related to the induction of a thermal effect. METHODS:A systematic literature search was conducted in PubMed, CINAHL, PEDro, EMBASE, SPORTdiscus and Scholar...

journal_title：Osteoarthritis and cartilage

authors： Laufer Y,Dar G

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To define for the first time the transcriptomes of normal and end-stage osteoarthritis (OA) hip cartilage. MATERIALS AND METHODS:RNA was isolated from cartilage within 2h of joint replacement surgery. Gene expression was analyzed using Agilent GeneSpring GX 11 following hybridization to Illumina Human HT-12 ...

journal_title：Osteoarthritis and cartilage

authors： Xu Y,Barter MJ,Swan DC,Rankin KS,Rowan AD,Santibanez-Koref M,Loughlin J,Young DA

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Hip labrum pathology has only begun to emerge as a significant source of groin pain in the last decade since the development of hip arthroscopy. Few data are available on the anatomy, histology and function of this structure. Moreover, no metabolic data exist at cellular level. The aim of this study was to ch...

journal_title：Osteoarthritis and cartilage

authors： Dhollander AA,Lambrecht S,Verdonk PC,Audenaert EA,Almqvist KF,Pattyn C,Verdonk R,Elewaut D,Verbruggen G

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of chondroitin sulfate and/or glucosamine hydrochloride in alleviating symptoms and improving the dysfunction of Kashin-Beck disease (KBD) patients. METHODS:We undertook a cluster-randomized, placebo-controlled trial in 251 patients with KBD. Participants were randomly all...

journal_title：Osteoarthritis and cartilage

authors： Yue J,Yang M,Yi S,Dong B,Li W,Yang Z,Lu J,Zhang R,Yong J

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Meniscus tear is a known risk factor for osteoarthritis (OA). Quantitative assessment of meniscus degeneration, prior to surface break-down, is important to identification of early disease potentially amenable to therapeutic interventions. This work examines the diagnostic potential of ultrashort echo time-en...

journal_title：Osteoarthritis and cartilage

authors： Williams A,Qian Y,Golla S,Chu CR

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Fourier transform infrared (FT-IR) spectroscopic imaging is a promising method that enables the analysis of spatial distribution of biochemical components within histological sections. However, analysis of FT-IR spectroscopic data is complicated since absorption peaks often overlap with each other. Second der...

journal_title：Osteoarthritis and cartilage

authors： Rieppo L,Saarakkala S,Närhi T,Helminen HJ,Jurvelin JS,Rieppo J

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS:One hundred fifty-eight knee joints from 133 patients that subsequently underwent total knee joint arthroplasty from January 2008 to December 2009 ...

journal_title：Osteoarthritis and cartilage

authors： Hwang SH,Jung KA,Lee WJ,Yang KH,Lee DW,Carter A,Park CH,Hunter DJ

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVES:The delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) technique is a method proposed for non-invasive measurement of cartilage glycosaminoglycan (GAG) content. In this method, gadopentetate (Gd-DTPA²⁻) is assumed to distribute in cartilage in inverse relation to the GAG distribution, thus allowing quant...

journal_title：Osteoarthritis and cartilage

authors： Salo EN,Nissi MJ,Kulmala KA,Tiitu V,Töyräs J,Nieminen MT

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO(2) and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these levels relate to arthroscopic findings of inflammation and degeneration. MATERIALS AND METHODS:Venous blood and synovial ...

journal_title：Osteoarthritis and cartilage

authors： Verwilghen DR,Enzerink E,Martens A,Franck T,Balligand M,Henrotin Y,Detilleux J,Serteyn D

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Sex hormones and reproductive factors may be important for osteoarthritis (OA). The aim of this study was to describe the associations of parity, use of hormone replacement therapy (HRT) and oral contraceptives (OCs) with cartilage volume, cartilage defects and radiographic OA in a population-based sample of ...

journal_title：Osteoarthritis and cartilage

authors： Wei S,Venn A,Ding C,Martel-Pelletier J,Pelletier JP,Abram F,Cicuttini F,Jones G

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To investigate the validity of joint space width (JSW) measurements in millimeters (mm) in hand osteoarthritis (OA) patients by comparison to controls, grading of joint space narrowing (JSN), and clinical features. METHODS:Hand radiographs of 235 hand OA patients (mean age 65 years, 83% women) and 471 contro...

journal_title：Osteoarthritis and cartilage

authors： Kwok WY,Bijsterbosch J,Malm SH,Biermasz NR,Huetink K,Nelissen RG,Meulenbelt I,Huizinga TW,van 't Klooster R,Stoel BC,Kloppenburg M

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Fetal cartilage anlage provides a framework for endochondral ossification and organization into articular cartilage. We previously reported differences between mechanical properties of talar cartilage anlagen and adult articular cartilage. However, the underlying development-associated changes remain to be es...

journal_title：Osteoarthritis and cartilage

authors： Mahmoodian R,Leasure J,Philip P,Pleshko N,Capaldi F,Siegler S

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:We determined whether baseline depressive symptoms, knee-related confidence and general psychological distress influenced changes in pain and function during 2 years of follow-up. DESIGN:We included persons in the Osteoarthritis Initiative (OAI) dataset with baseline pain of 1 or greater on a 0-10 scale in a...

journal_title：Osteoarthritis and cartilage

authors： Riddle DL,Kong X,Fitzgerald GK

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:The number of effective knee osteoarthritis (OA) interventions, especially those tailored to specific compartmental involvement, are small. The objective of this study was to determine the efficacy of a realigning patellofemoral (PF) brace in improving pain and function among persons with symptomatic lateral PF...

journal_title：Osteoarthritis and cartilage

authors： Hunter DJ,Harvey W,Gross KD,Felson D,McCree P,Li L,Hirko K,Zhang B,Bennell K

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Femoroacetabular impingement (FAI) is a pathomechanical process, which may cause hip pain, disability and early development of hip osteoarthritis (OA) in young and active adults. Patients with FAI experience functional disability during dynamic weight-bearing activities, which could originate from weakness of...

journal_title：Osteoarthritis and cartilage

authors： Casartelli NC,Maffiuletti NA,Item-Glatthorn JF,Staehli S,Bizzini M,Impellizzeri FM,Leunig M

更新日期：2011-07-01 00:00:00

abstract：INTRODUCTION:Systematic reviews agree that knee osteoarthritis (OA) is related to occupational activities, but have not quantified the overall risks. METHODS:Systematic review of observational studies of knee OA and occupation. Job titles, elite sport, heavy work, kneeling, and other activities were included. Relative...

journal_title：Osteoarthritis and cartilage

authors： McWilliams DF,Leeb BF,Muthuri SG,Doherty M,Zhang W

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Articular cartilage of the mandibular condyle has limited ability to regenerate itself after injury. This study was to investigate whether osteochondral defects in mandibular condyle could be repaired by NELL-1(NEL-like molecule-1)-modified autogenous bone marrow mesenchymal stem cells (BMMSCs) and poly lacti...

journal_title：Osteoarthritis and cartilage

authors： Zhu S,Zhang B,Man C,Ma Y,Hu J

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:To determine the natural history of cartilage damage and of osteoarthritis (OA) progression using magnetic resonance imaging (MRI); to evaluate whether OA progression varies by stage of disease. METHODS:A population-based cohort with knee pain was assessed clinically, with X-ray (Kellgren-Lawrence [KL] grad...

journal_title：Osteoarthritis and cartilage

authors： Cibere J,Sayre EC,Guermazi A,Nicolaou S,Kopec JA,Esdaile JM,Thorne A,Singer J,Wong H

更新日期：2011-06-01 00:00:00

abstract：:The design and execution of prevention trials for OA have methodological issues that are distinct from trials designed to impact prevalent disease. Disease definitions and their precise and sensitive measurement, identification of high-risk populations, the nature of the intervention (pharmaceutical, nutraceutical, be...

journal_title：Osteoarthritis and cartilage

authors： Jordan JM,Sowers MF,Messier SP,Bradley J,Arangio G,Katz JN,Losina E,Rovati L,Bachtell N,Cooper C,Spector T,Zhang W,Gardiner J,Wahba M

更新日期：2011-05-01 00:00:00

abstract：:Osteoarthritis is characterized by progressive breakdown of articular cartilage. This review summarizes findings of the last year, which shed new light on mechanisms and factors involved in cartilage loss. Evidence is accumulating that the transcription factor hypoxia-inducible factor-2α (HIF-2α) is highly enhanced in...

journal_title：Osteoarthritis and cartilage

authors： van den Berg WB

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to determine if the electroporation-mediated gene transfer of SOX trio enhances the chondrogenic potential of adipose stem cells (ASCs). DESIGN:ASCs were transfected with SOX trio genes using an electroporation technique and cultured for 3 weeks. The pellets were analyzed for...

journal_title：Osteoarthritis and cartilage

authors： Im GI,Kim HJ

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:The discovery of small molecular compounds that expand cartilage is needed. We searched for small molecular compounds that expand cartilage or enhance the actions of bone morphogenetic proteins (BMPs) on cartilage. DESIGN:Metatarsal primordial cartilage explants prepared from 14.5 days postcoitum (d.p.c.) mo...

journal_title：Osteoarthritis and cartilage

authors： Ikegami D,Iwai T,Ryo S,Gu N,Sugiyama T,Oh I,Yoshikawa H,Tsumaki N

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:To compare femorotibial cartilage thickness changes over a 2- vs a 1-year observation period in knees with radiographic knee osteoarthritis (OA). METHODS:One knee of 346 Osteoarthritis Initiative (OAI) participants was studied at three time points [baseline (BL), year-1 (Y1), year-2 (Y2) follow-up]: 239 usin...

journal_title：Osteoarthritis and cartilage

authors： Wirth W,Larroque S,Davies RY,Nevitt M,Gimona A,Baribaud F,Lee JH,Benichou O,Wyman BT,Hudelmaier M,Maschek S,Eckstein F,OA Initiative Investigators Group.

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Differentiated articular chondrocytes express a functional bisoform of the leptin receptor (LRb); however, leptin-LRb signaling in these cells is poorly understood. We hypothesized that leptin-LRb signaling in articular chondrocytes functions to modulate canonical Wnt signaling events by altering the expressi...

journal_title：Osteoarthritis and cartilage

authors： Ohba S,Lanigan TM,Roessler BJ

更新日期：2010-12-01 00:00:00

abstract：UNLABELLED:Injury to articular cartilage leads to degenerative changes resulting in a loss of mechanical and biochemical properties. In engineered cartilage, the injury response of developing constructs is unclear. OBJECTIVE:To characterize the cellular response of tissue-engineered constructs cultured in chemically-d...

journal_title：Osteoarthritis and cartilage

authors： Tan AR,Dong EY,Ateshian GA,Hung CT

更新日期：2010-12-01 00:00:00